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Related Experiment Videos

Temporary brittle bone disease: a true entity?

M E Miller1

  • 1Department of Pediatrics, Wright State University School of Medicine and the Children's Medical Center, Dayton, OH 45404, USA.

Seminars in Perinatology
|May 20, 1999
PubMed
Summary
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Temporary brittle bone disease, characterized by fractures in infants, is linked to reduced fetal movement and low bone density. This study supports its existence as a distinct medical condition.

Area of Science:

  • Pediatrics
  • Orthopedics
  • Medical Genetics

Background:

  • Temporary brittle bone disease (TBBD) is a recently identified condition causing fractures in infants.
  • It is often misdiagnosed as child abuse due to unexplained fractures.
  • Establishing TBBD as a distinct entity is crucial for accurate diagnosis and treatment.

Purpose of the Study:

  • To investigate the association between TBBD and factors like fetal movement and bone density.
  • To provide evidence supporting the existence of TBBD as a real medical condition.
  • To aid clinicians in diagnosing TBBD.

Main Methods:

  • Review of 26 infant cases meeting TBBD criteria.
  • Bone density measurements (CT or radiography) in nine infants.

Related Experiment Videos

  • Analysis of historical data on fetal movement and intrauterine confinement.

    • Main Results:

    • A strong correlation was found between TBBD and decreased fetal movement, often due to intrauterine confinement.
    • Eight out of nine infants studied exhibited low bone density measurements.
    • These findings align with the mechanostat-mechanical load theory of bone formation.

    Conclusions:

    • Temporary brittle bone disease is a genuine medical condition.
    • Decreased fetal movement and intrauterine confinement are significant associated factors.
    • Bone density measurements and historical data are valuable diagnostic tools for TBBD.