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Related Experiment Videos

Antibiotic release from biodegradable PHBV microparticles.

D Sendil1, I Gürsel, D L Wise

  • 1Middle East Technical University, Department of Biological Sciences, Biotechnology Research Unit, Ankara 06531, Turkey.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|May 20, 1999
PubMed
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This study developed a novel controlled-release system using poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) microspheres for periodontal disease treatment. Neutralizing tetracycline significantly enhanced encapsulation efficiency and controlled its release, showing promise for long-term antibiotic delivery.

Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Periodontal Therapeutics

Background:

  • Periodontal diseases require effective, long-term treatment strategies.
  • Controlled release systems offer a promising approach for sustained drug delivery.
  • Biodegradable polyesters like PHBV are suitable for developing such systems.

Purpose of the Study:

  • To develop and characterize a novel controlled release system for tetracycline using PHBV.
  • To investigate the effect of tetracycline form (acidic vs. neutral) on encapsulation and release.
  • To evaluate the influence of emulsifier concentration on system properties.

Main Methods:

  • Preparation of PHBV microspheres and microcapsules loaded with tetracycline (acidic and neutral forms).

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  • Utilized w/o/w double emulsion technique for microcapsule fabrication.
  • Investigated encapsulation efficiency, loading, release kinetics, and morphology.

    • Main Results:

    • Emulsifier concentration (PVA, gelatin) significantly impacted encapsulation efficiency.
    • Neutralizing tetracycline hydrochloride (TCN) dramatically increased encapsulation efficiency (51.9-65.3%) compared to acidic form (18.1-30.1%).
    • Drug release followed Higuchi's model, indicating diffusion-controlled release, and was complete before significant PHBV degradation.

    Conclusions:

    • PHBV-based microcapsules are effective for controlled tetracycline delivery in periodontal therapy.
    • Neutralization of tetracycline is crucial for achieving high encapsulation efficiency.
    • The developed system demonstrates potential for improved long-term management of periodontal diseases.