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Assessment of tissue oxygenation.

P W Robertson¹, B B Hart

¹Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina, USA.

Respiratory Care Clinics of North America

|May 20, 1999

Summary

Maintaining aerobic metabolism requires adequate tissue oxygenation. This summary reviews methods for assessing oxygen supply and demand, crucial for hyperbaric medicine applications.

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Area of Science:

Biomedical Engineering
Physiology
Medical Imaging

Background:

Efficient ATP production relies on continuous oxygen supply to tissues, maintaining aerobic metabolism.
Impaired tissue oxygenation characterizes conditions like nonhealing wounds, infections, and CO poisoning.
Hyperbaric medicine efficacy depends on understanding tissue oxygen supply and demand.

Purpose of the Study:

To review current and emerging methods for assessing tissue oxygenation adequacy.
To discuss the clinical and experimental applications of these assessment methods.
To emphasize the role of these methods in hyperbaric medicine.

Main Methods:

Blood gas analysis
Transcutaneous oxygen measurement
Gastric tonometry
Pulse oximetry
Near-infrared spectroscopy
Functional MR imaging
MR spectroscopy
Electron paramagnetic resonance
Positron emission tomography
Single photon emission computed tomography

Main Results:

A comprehensive overview of diverse methods for evaluating tissue oxygenation is presented.
The discussion highlights the applicability of these techniques in various clinical and research settings.
The relevance of these methods to hyperbaric oxygen therapy is emphasized.

Conclusions:

Accurate assessment of tissue oxygenation is vital for managing conditions involving impaired oxygen supply.
A range of technologies exists for measuring tissue oxygenation, aiding clinical decision-making.
These assessment tools are integral to advancing hyperbaric medicine and patient care.

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