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Updated: Aug 12, 2026

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model
Published on: January 12, 2022
Interstitial nephritis and uveitis syndrome presenting with bilateral optic disk edema
1Department of Ophthalmology, Southern California Permanente Medical Group, USA. mark.d.sherman@kp.org
Purpose:
To report a rare presentation of the tubulointerstitial nephritis and uveitis syndrome.
Method:
Case report. A 34-year-old woman underwent extensive clinical and laboratory evaluation of bilateral intermediate uveitis and optic nerve edema.
Results:
Laboratory evaluation and nephrology consultation led to a diagnosis of tubulointerstitial nephritis. The condition resolved with the use of topical and systemic corticosteroids and the discontinuation of ibuprofen.
Conclusions:
Tubulointerstitial nephritis and uveitis syndrome is uncommon. It may present with anterior or intermediate uveitis. Chronic intermediate uveitis can cause optic nerve and macular edema. A thorough medical evaluation of any patient presenting with uveitis and systemic disease is essential to the diagnosis and management of uveitis.
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