Related Experiment Video
Updated: Aug 11, 2026

Rat Model of Photochemically-Induced Posterior Ischemic Optic Neuropathy
Published on: November 29, 2015
Features of amiodarone-induced optic neuropathy
D C Macaluso1, W T Shults, F T Fraunfelder
1Casey Eye Institute, Oregon Health Sciences University, Portland, USA. Macaluso@aol.com
Purpose:
To report clinical features of amiodarone-induced optic neuropathy and outline the differentiation of amiodarone optic neuropathy from nonarteritic anterior ischemic optic neuropathy.
Method:
We reviewed data from 73 patients reported to have developed an optic neuropathy while taking amiodarone.
Results:
Amiodarone optic neuropathy is characterized by an insidious onset, slow progression, bilateral visual loss, and protracted disk swelling that tends to stabilize within several months of discontinuing the medication. Nonarteritic ischemic optic neuropathy is characterized by acute, unilateral visual loss that is usually complete at onset, with resolution of disk edema over several weeks.
Conclusion:
Unique clinical features of amiodarone-induced optic neuropathy may help clinicians diagnose and distinguish between amiodarone-induced optic neuropathy and nonarteritic anterior ischemic optic neuropathy.
Related Concept Videos
Glaucoma: Overview
Open Angle Glaucoma: Treatment
Drugs such as carbonic anhydrase inhibitors, α2- and...
Angle Closure Glaucoma: Treatment
Photoreceptors and Visual Pathways
Dysrhythmias IV: Characteristics of Bradyarrhythmias
Diabetic Retinopathy

