The epidemiology of bacterial sepsis

As a result of better understanding of pathogenesis, new definitions of sepsis have been proposed, and the complexity of this syndrome is clearer. Population-based studies of bloodstream infections--what now is called sepsis--have helped us to understand the natural history of this very frequent problem. The mortality and morbidity of each of the systemic inflammatory response syndrome stages have been described; our ability to better understand and predict these stages will help us to make better therapeutic decisions.