Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Measuring central-chemoreflex sensitivity in man: rebreathing and steady-state methods compared.

R M Mohan1, C E Amara, D A Cunningham

  • 1Department of Physiology, University of Toronto, Ontario, Canada.

Respiration Physiology
|May 27, 1999
PubMed
Summary

The modified rebreathing method offers the most accurate estimation of central chemoreflex sensitivity. This method proved superior to steady-state and Read rebreathing techniques in accurately assessing ventilatory responses to carbon dioxide.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Quality assessment of online patient information on upper gastrointestinal endoscopy using the modified Ensuring Quality Information for Patients tool.

Annals of the Royal College of Surgeons of England·2024
Same author

Improved White Matter Cerebrovascular Reactivity after Revascularization in Patients with Steno-Occlusive Disease.

AJNR. American journal of neuroradiology·2018
Same author

Paediatric obstructive sleep apnoea: is our operative management evidence-based?

The Journal of laryngology and otology·2018
Same author

Paediatric obstructive sleep apnoea: can our identification of surgical candidates be evidence-based?

The Journal of laryngology and otology·2018
Same author

Vascular Dysfunction in Leukoaraiosis.

AJNR. American journal of neuroradiology·2016
Same author

Reliability of TMS metrics in patients with chronic incomplete spinal cord injury.

Spinal cord·2016

Area of Science:

  • Physiology
  • Respiratory Control

Background:

  • Accurate assessment of central chemoreflex sensitivity is crucial for understanding respiratory control.
  • Existing methods like steady-state and rebreathing tests present challenges in precise sensitivity estimation.

Purpose of the Study:

  • To compare the accuracy of central chemoreflex sensitivity estimations between steady-state and rebreathing techniques.
  • To identify factors influencing the reliability of each method for assessing ventilatory responses to carbon dioxide.

Main Methods:

  • Subjects underwent dynamic end-tidal forcing experiments for steady-state ventilatory response to carbon dioxide measurements.
  • Rebreathing experiments utilized Read's technique and a modified method with prior hyperventilation.
  • Central chemoreflex sensitivities were calculated from the slopes of ventilatory responses using different data points.

Related Experiment Videos

Main Results:

  • Steady-state method yielded significantly lower sensitivities compared to the Read rebreathing technique.
  • The modified rebreathing method showed the closest agreement with steady-state results when specific data points were used.
  • Factors like ventilation response limits and inclusion of sub-threshold data affected estimations.

Conclusions:

  • The modified rebreathing method is recommended for the most reliable estimation of central chemoreflex sensitivity.
  • Understanding methodological limitations is key for accurate interpretation of chemoreflex sensitivity data.