Chemical modification of antibiotic eremomycin at the asparagine side chain
E N Olsufyeva1, T F Berdnikova, O V Miroshnikova
1Institute of New Antibiotics, Russian Academy of Medical Sciences, Moscow, B. Pirogovskaya.
The Journal of Antibiotics
|May 29, 1999
Abstract:
AA3-Carboxyeremomycin 2, obtained by selective hydrolysis of antibiotic eremomycin was used as a starting compound for the eremomycin chemical modifications at the asparagine side chain to be transformed into eremomycin AA3, AA7 bis-amides (3a-c). Bis-benzylamide 3b displayed an activity (8 microg/ml) against an E. faecium VanA strain.
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