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Updated: Apr 15, 2026

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Published on: October 31, 2013
[New antibiotics produced by Bacillus subtilis strains].
Two Bacillus subtilis strains from Pholiota squarrosa fungus produce novel antibiotics effective against resistant bacteria like MRSA. These compounds also show antifungal properties, offering potential new treatments.
Area of Science:
- Microbiology
- Mycology
- Biochemistry
Context:
- Bacillus subtilis strains were isolated from the fruiting body of the basidiomycete fungus Pholiota squarrosa.
- Antibiotic resistance in bacteria, including MRSA and glycopeptide-resistant Leuconostoc mesenteroides, is a growing global health concern.
Purpose:
- To identify and characterize novel antibiotic compounds produced by Bacillus subtilis strains.
- To evaluate the antibacterial and antifungal activities of these novel compounds.
Summary:
- Two Bacillus subtilis strains, INA 01085 and INA 01086, were isolated from Pholiota squarrosa.
- These strains demonstrated broad-spectrum antibacterial activity against resistant pathogens, including methicillin-resistant Staphylococcus aureus (MRSA) and glycopeptide-resistant Leuconostoc mesenteroides.
- Strain INA 01086 produced a cyclic polypeptide antibiotic, while strain INA 01085 produced a similar compound with two unidentified nonproteinaceous amino acids. Both compounds were effective against gram-positive bacteria and overcame natural resistance.
Impact:
- Discovery of new antibiotic compounds with potential applications in combating drug-resistant bacterial infections.
- Identification of Bacillus subtilis strains as a source of novel antimicrobial agents.
- Contribution to the understanding of microbial secondary metabolites and their resistance-breaking mechanisms.
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