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Related Experiment Videos

Repetitive abortion in Neospora-infected ewes.

W R Jolley1, M M McAllister, A M McGuire

  • 1Department of Veterinary Sciences, University of Wyoming, Laramie 82070, USA.

Veterinary Parasitology
|May 29, 1999
PubMed
Summary

Experimental Neospora caninum infection in pregnant ewes caused abortion and birth defects. Repeated infections highlight similarities between ovine and bovine neosporosis, impacting fetal development and lamb health.

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Area of Science:

  • Veterinary Parasitology
  • Reproductive Immunology
  • Ovine Pathology

Background:

  • Neospora caninum is a significant cause of abortion in livestock.
  • Experimental studies have explored Neospora caninum infection in various animal models.
  • Understanding host-parasite interactions is crucial for disease control.

Purpose of the Study:

  • To investigate the effects of repeated Neospora caninum tachyzoite inoculation in pregnant ewes.
  • To assess the clinical, histopathological, and serological outcomes of infection.
  • To compare neosporosis manifestations in sheep with those reported in cattle.

Main Methods:

  • Pregnant ewes were inoculated with Neospora caninum tachyzoites in single or repeated years (1995, 1996).
  • Lambs and fetuses were examined for clinical signs, lesions, and presence of Neospora zoites.

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  • Serological responses were monitored to assess systemic infection.

    • Main Results:

    • Ewes inoculated in 1995 and/or 1996 experienced abortions or delivered weak/normal lambs in 1996.
    • Histologic examination revealed lesions and zoites consistent with Neospora in fetuses and lambs.
    • Systemic neosporosis was indicated by serologic responses and fetal/lamb infections, despite negative cultures from maternal tissues.

    Conclusions:

    • Repeated Neospora caninum infection in ewes leads to adverse pregnancy outcomes.
    • Clinical and pathological findings in experimentally infected sheep resemble those in naturally infected cattle.
    • These findings reinforce the established similarities of neosporosis between sheep and cattle.