Related Experiment Video

Updated: Aug 14, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Published on: February 9, 2011

Treatment of acute sinusitis in childhood with ceftibuten

M W Simon1

  • 1Department of Pediatrics, University of Kentucky, Lexington, USA.

Clinical Pediatrics
|June 1, 1999
PubMed

Insights

This study found that longer treatment durations for acute sinusitis in children may improve outcomes. A 20-day course of ceftibuten showed 100% effectiveness, compared to other regimens.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Pharmacology

Background:

  • Acute sinusitis is a frequent pediatric illness with potential for serious complications if untreated.
  • Amoxicillin resistance due to beta-lactamase producing bacteria and altered penicillin-binding proteins impacts treatment efficacy.
  • Novel antibiotic strategies are needed for effective acute sinusitis management in children.

Purpose of the Study:

  • To compare the clinical effectiveness of varying durations of ceftibuten therapy (10, 15, and 20 days) against erythromycin-sulfisoxazole (14 days) for treating acute sinusitis in children.

Main Methods:

  • A comparative study evaluating treatment outcomes for acute sinusitis.
  • Patients received either 10, 15, or 20 days of ceftibuten or 14 days of erythromycin-sulfisoxazole.
  • Clinical response rates were assessed for each treatment group.

Main Results:

  • Both ceftibuten and erythromycin-sulfisoxazole demonstrated high clinical response rates.
  • Erythromycin-sulfisoxazole achieved a 96% clinical response.
  • Ceftibuten showed a 92% response for 10- or 15-day courses and 100% for a 20-day course.

Conclusions:

  • Ceftibuten and erythromycin-sulfisoxazole are effective treatments for pediatric acute sinusitis.
  • A 20-day course of ceftibuten therapy resulted in the highest clinical resolution rate (100%).
  • Extended treatment durations may enhance the resolution of acute sinusitis in children.

More Related Videos

Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections16:56

Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections

Published on: August 30, 2014

Growing a Cystic Fibrosis-Relevant Polymicrobial Biofilm to Probe Community Phenotypes03:53

Growing a Cystic Fibrosis-Relevant Polymicrobial Biofilm to Probe Community Phenotypes

Published on: April 19, 2024

Related Concept Videos

Acute Pharyngitis01:30

Acute Pharyngitis

Introduction
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
Chronic Pharyngitis01:23

Chronic Pharyngitis

Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
Tonsillitis I: Introduction01:30

Tonsillitis I: Introduction

Tonsillitis is inflammation of the tonsils, which are two lymphoid tissue masses at the back of the throat. This condition can cause discomfort and irritation in the throat.
Etiology
Three primary contributing factors have been identified.
Tonsillitis II: Management01:26

Tonsillitis II: Management

This lesson will focus on the different treatment options for managing tonsillitis, which typically depend on the cause and severity.
Acne Infection01:27

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
Respiratory Syncytial Virus Disease01:29

Respiratory Syncytial Virus Disease

Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...