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Subcutaneous Fusarium foot abscess in a renal transplant patient
M Girardi1, E J Glusac, S Imaeda
1Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut 06520-8059, USA.
Abstract:
Fusarium species are ubiquitous plant and grain phytopathogens that rarely cause opportunistic infections in immunocompromised patients. While disseminated Fusarium infections are almost always fatal, localized infections may be responsive to a combination of systemic antibiotic therapy and surgical debridement. We present a diabetic renal transplant patient who developed a foot abscess due to Fusarium solani. Infection persisted despite aggressive surgical debridement and a 3-month course of intravenous liposomal amphotericin B.
Insights
Fusarium solani caused a persistent foot abscess in a diabetic kidney transplant patient. Aggressive treatment, including surgery and antifungal medication, proved ineffective, highlighting treatment challenges.
Area of Science:
- Mycology
- Infectious Diseases
- Transplant Medicine
Background:
- Fusarium species are common plant pathogens.
- Opportunistic infections in immunocompromised individuals are rare but serious.
- Disseminated Fusarium infections are often fatal, while localized infections may respond to treatment.
Observation:
- A diabetic patient with a renal transplant developed a foot abscess.
- The abscess was caused by Fusarium solani.
Findings:
- The infection persisted despite aggressive surgical debridement.
- A 3-month course of intravenous liposomal amphotericin B was also ineffective.
Implications:
- This case highlights the potential for difficult-to-treat Fusarium infections in transplant recipients.
- It underscores the need for novel therapeutic strategies for invasive fusariosis.
- Early recognition and aggressive management are crucial, but may not always be successful.