Screening for protein-protein interactions
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Identifying Protein-protein Interaction Sites Using Peptide Arrays
Published on: November 18, 2014
1University of Medical Dentistry of New Jersey, Clinical Institute of New Jersey, New Brunswick 08901, USA.
Methods in Enzymology
|June 1, 1999
Abstract:
The assays described above can be used to screen for cellular proteins that can interact with a protein of interest, to screen for mutant proteins that retain the ability to bind to its partner, and to identify the domains and amino acids involved in known protein-protein interactions. Nonetheless, the biological significance of some of these interactions needs to be confirmed by appropriate cellular studies.
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