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Recurrent convulsions and cardiac conduction disturbances after propafenone overdose
M O Rambourg-Schepens1, F Grossenbacher, M Buffet
1Clinical Toxicology Unit-Toxicovigilance/Intensive Care Unit, Centre Hospitalier Universitaire, Reims, France.
Veterinary and Human Toxicology
|June 1, 1999
Abstract:
Propafenone is a class Ic antiarrhythmic agent which also exhibits beta-adrenergic and fast sodium channel blockade. We report a case of severe poisoning in a 24-y-old woman who suffered a seizure 1 h after the intentional ingestion of 2.7 g propafenone, and had a recurrence of convulsion on arrival at the hospital. She also developed severe arrhythmia during her hospital course. She recovered uneventfully with supportive treatment.