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[Hyperthermia-induced priming effect in neutrophil granulocytes]
D Löer1, J Elsner, A Michalsen
1Sanitas Dr. Kohler-Parkkliniken, Bad Elster, Munchen, Deutschland.
Forschende Komplementarmedizin
|June 3, 1999
Summary
Whole-body infrared-A irradiation (WBIAI) hyperthermia primes human polymorphonuclear leukocytes (PMN) to produce more reactive oxygen radicals (ROS). This immune priming effect in PMN lasts for hours after treatment, suggesting enhanced immune response potential.
Area of Science:
- Immunology
- Hyperthermia research
- Cellular immunology
Context:
- Whole-body infrared-A irradiation (WBIAI) is a novel hyperthermia method.
- Clinical benefits for chronic infections are reported.
- The immunological mechanisms require elucidation.
Purpose:
- To investigate the immunological background of WBIAI.
- To determine if hyperthermia induces priming effects in human polymorphonuclear leukocytes (PMN).
Summary:
- Isolated PMN from 8 volunteers were stimulated post-WBIAI treatment.
- Reactive oxygen species (ROS) production was measured via chemiluminescence.
- Measurements were taken at 0, 60, 240, and 510 minutes post-treatment.
Impact:
- Hyperthermia induced a significant, lasting increase in PMN ROS production.
- This suggests a hyperthermia-dependent priming effect on the immune system.
- Further research is needed to identify responders and specific disease applications.