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Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
Published on: October 14, 2021
Recent advances on cutaneous lymphoma epidemiology
G Dobos1, M Miladi2, L Michel3
1Dermatology Department, Saint-Louis Hospital, AP-HP, Paris, France; INSERM U976 Human Immunology, Pathophysiology and Immune Therapies, Paris, France; Université de Paris, Paris, France; Department of Dermatology, Venerology and Allergology, Charité-Universitätsmedizin Berlin, Germany.
Epidemiology of cutaneous lymphomas, including T-cell (CTCL) and B-cell (CBCL) types, shows increasing incidence globally. Despite variations by country, rare lymphoma frequencies remain stable, aided by improved diagnostics.
Area of Science:
- Dermatology
- Hematology
- Oncology
Background:
- Primary cutaneous lymphomas encompass T-cell (CTCL) and B-cell (CBCL) malignancies with varied prognoses.
- Limited epidemiological data exists for these rare cancers.
- Recent advancements in diagnostics and biomarkers improve classification.
Purpose of the Study:
- To review current findings on CTCL and CBCL incidence.
- To analyze trends in their occurrence over time.
- To explore potential causes and consequences.
Main Methods:
- Systematic literature review of epidemiological studies.
- Analysis of incidence data for CTCL and CBCL.
- Synthesis of findings on diagnostic criteria and biomarkers.
Main Results:
- Global incidence of both CTCL and CBCL is reportedly increasing.
- Epidemiological patterns differ across countries, yet rare lymphoma frequencies are consistent.
- Enhanced diagnostic criteria and biomarkers facilitate better case classification.
Conclusions:
- The incidence of cutaneous lymphomas is rising, necessitating further epidemiological research.
- Improved diagnostic tools are crucial for accurate classification and understanding of these malignancies.
- Continued monitoring of epidemiological trends is vital for patient outcomes.
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