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Effects of Fructus schizandrae on cycloheximide-induced amnesia in rats
M T Hsieh1, M L Tsai, W H Peng
1Institute of Chinese Pharmaceutical Sciences, China Medical College, Taichung, Taiwan, R.O.C.
Phytotherapy Research : PTR
|June 3, 1999
Abstract:
The effects of Fructus Schisandrae (Schizandra Chinensis, (FS) on cycloheximide (CXM)-induced amnesia by using a passive avoidance task were studied in rats. FS at 0.25 and 0.75 g/kg administered for 1 week significantly prolonged the CXM-shortened step-through latency (STL). Of the fractions (n-hexane, chloroform and water), only the water fraction at 25 mg/kg administered for 1 week prolonged the CXM-shortened STL. These results suggest that the water fraction is the main active fraction of FS.