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Related Experiment Videos

Changes in aggressive behavior during withdrawal from long-term marijuana use.

E M Kouri1, H G Pope, S E Lukas

  • 1Biological Psychiatry Laboratory, McLean Hospital/Harvard Medical School, Belmont, Massachusetts 02478, USA.

Psychopharmacology
|June 3, 1999
PubMed
Summary
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Chronic marijuana use can lead to increased aggressive behavior during withdrawal. This aggression returns to normal levels after 28 days of abstinence, suggesting it

Area of Science:

  • Neuroscience
  • Psychology
  • Addiction Medicine

Background:

  • Marijuana is the most commonly abused illicit drug in the United States.
  • The effects of chronic marijuana use on human aggressive behavior during withdrawal remain unclear.

Purpose of the Study:

  • To investigate the pattern and duration of changes in aggressive behavior in long-term marijuana users.
  • To assess aggressive behavior changes during a 28-day abstinence period verified by daily urine tests.

Main Methods:

  • Recruited chronic marijuana users with extensive usage history (≥5000 occasions).
  • Measured aggressive behavior using the Point Subtraction Aggression Paradigm.
  • Assessed participants on days 0, 1, 3, 7, and 28 of a 28-day detoxification period.

Related Experiment Videos

Main Results:

  • Chronic marijuana users exhibited increased aggressive behavior on days 3 and 7 of abstinence compared to controls and baseline.
  • Aggressive responding returned to pre-withdrawal levels by day 28.
  • Minor, non-significant changes in depression and anxiety scores were observed.

Conclusions:

  • Findings support the existence of an abstinence syndrome associated with chronic marijuana use.
  • Aggressive behavior should be considered an additional component of marijuana withdrawal syndrome.