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A novel acute-phase marker: lipopolysaccharide binding protein (LBP)
1Institut für Mikrobiologie und Hygiene, Medizinische Fakultät Charite, Humboldt-Universität zu Berlin, Germany. ralf.schumann@charite.de
Clinical Chemistry and Laboratory Medicine
|June 3, 1999
Summary
Lipopolysaccharide (LPS) binding protein (LBP) shows promise as a novel acute-phase protein marker for early and specific detection of sepsis. Monitoring LBP levels can improve diagnosis and disease management, potentially reducing mortality rates.
Area of Science:
- Biochemistry
- Immunology
- Medical Diagnostics
Background:
- Acute phase proteins are crucial for monitoring homeostasis and disease progression.
- Current serum markers lack specificity for early sepsis and systemic inflammatory response syndrome (SIRS) detection, despite high mortality rates.
- A need exists for more precise diagnostic tools for sepsis and related disorders.
Purpose of the Study:
- To introduce Lipopolysaccharide (LPS) binding protein (LBP) as a novel acute-phase protein for host defense.
- To evaluate LBP's potential as an addition to current diagnostic and monitoring strategies for sepsis.
- To review evidence supporting LBP's role in host response to endotoxin stimulation.
Main Methods:
- Review of in vitro studies investigating LBP function.
- Analysis of results from animal models of sepsis.
- Perspective on ongoing clinical studies involving LBP.
Main Results:
- Lipopolysaccharide (LPS) binding protein (LBP) is a class 1 acute-phase protein that binds and transfers bacterial LPS.
- Serum LBP levels significantly impact the host's response to endotoxin and defense against sepsis.
- Evidence suggests LBP is a key parameter for monitoring acute phase response and host endotoxin defense.
Conclusions:
- LBP is a promising novel acute-phase protein with significant biological functions in host defense.
- LBP may serve as a valuable addition for the diagnosis and monitoring of sepsis.
- LBP, alongside other LPS-recognizing molecules, is important for assessing the host's reaction to LPS challenge.