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Sleep of children with enuresis: a polysomnographic study
T Nevéus1, A Stenberg, G Läckgren
1Department of Pediatrics, Uppsala, Sweden. tryggve.neveus@pediatrik.uu.se
Insights
Children with enuresis void during sleep, primarily non-rapid eye movement stages. Desmopressin responders void early or late, while non-responders void throughout the night.
Area of Science:
- Pediatric Sleep Medicine
- Urology
- Sleep Disorders
Background:
- Nocturnal enuresis affects many children, impacting quality of life.
- Understanding bladder voiding patterns during sleep is crucial for effective treatment.
Purpose of the Study:
- To investigate the relationship between sleep stages and bladder voiding in children with enuresis.
- To compare voiding patterns in desmopressin responders versus non-responders.
Main Methods:
- Polysomnography was used to record sleep and voiding events in 25 children (aged 7-17) with monosymptomatic nocturnal enuresis.
- 52 nights of data were analyzed, identifying 37 enuretic events.
- Children were categorized as responders (n=7) or non-responders (n=16) to desmopressin treatment.
Main Results:
- The average time from sleep onset to the first voiding was 3 hours and 20 minutes.
- Voiding events occurred most frequently during non-rapid eye movement sleep stages (Stage 2: 19 events, Stage 3: 7 events, Stage 4: 10 events).
- Desmopressin responders voided early or late in the night, unlike non-responders whose voiding was evenly distributed.
Conclusions:
- Enuretic events in children are primarily associated with non-rapid eye movement sleep.
- Distinct nocturnal voiding patterns differentiate desmopressin responders from non-responders, suggesting targeted treatment approaches.
Objective:
To evaluate relationships between bladder voiding and sleep in children with enuresis.
Methods:
Polysomnographic recordings were obtained from 25 children, aged 7 to 17 years, with monosymptomatic nocturnal enuresis. During 52 recorded nights, 37 enuretic events were detected. Responders (n = 7) and nonresponders (n = 16) to desmopressin treatment were compared.
Results:
The mean latency between sleep onset and the first bladder voiding was 3 hours 20 minutes (SD = 2 hours 5 minutes). The number of voidings were 19, 7, 10, and 1 occurring during stages 2, 3, and 4, and rapid-eye movement sleep, respectively. Desmopressin responders were found to void during the early or late part of the night, whereas the voidings of the nonresponders were dispersed evenly throughout the night (chi2 = 8.09).
Conclusions:
The enuretic event is a predominantly non-rapid eye movement sleep phenomenon. Responders and nonresponders to desmopressin treatment void during different parts of the night.