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Related Experiment Videos

[Round Table: Urticaria in relation to infections].

A Bilbao1, J M García, I Pocheville

  • 1Hospital de Cruces, Vizcaya, España.

Allergologia Et Immunopathologia
|June 3, 1999
PubMed
Summary

Acute urticaria in children is often linked to viral respiratory infections, particularly in infants. Antibiotic use may precede rash, but subsequent antibiotic exposure is typically well-tolerated.

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Area of Science:

  • Pediatric Allergy and Immunology
  • Infectious Diseases
  • Dermatology

Background:

  • Acute urticaria in children can be associated with underlying infectious illnesses.
  • Identifying the etiology of infectious-associated urticaria is crucial for appropriate management.
  • The role of atopy and prior urticarial episodes requires investigation.

Purpose of the Study:

  • To investigate the clinical and analytical characteristics of infectious disease-related urticaria in children.
  • To determine the likely causes of these infectious diseases.
  • To assess atopic predisposition, previous urticaria history, and the influence of antibiotics.

Main Methods:

  • A transversal, observational study conducted in a tertiary hospital's Pediatric Allergy Outpatient Clinic.

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  • Involved 44 children (1-12 years) with acute urticaria and concurrent infectious/febrile illness.
  • Utilized clinical evaluation, physical examination, and laboratory tests including blood counts, inflammatory markers, liver enzymes, and serological/viral assays for common pathogens.

    • Main Results:

    • Respiratory tract infections were present in 90.9% of patients; viral infections were suspected in 79.5%.
    • Enterovirus was significantly associated with acute urticaria (p=0.0054).
    • Antibiotic treatment preceded urticaria in 47.7% of cases, but subsequent antibiotic challenge was well-tolerated.

    Conclusions:

    • Infectious-associated urticarial rash in children is commonly linked to viral respiratory infections, especially in infants.
    • While antibiotics are frequently associated with urticaria development, they are generally safe upon re-challenge.
    • Further research can clarify the specific mechanisms linking viral infections and urticaria.