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Related Experiment Videos

Unusual giant comedo naevus.

C L Fletcher1, K M Acland, A V Powles

  • 1Department of Dermatology, The Central Middlesex Hospital, London, UK.

Clinical and Experimental Dermatology
|June 3, 1999
PubMed
Summary

Extensive comedo naevi crossing the midline are rare and typically present with associated abnormalities. This case highlights an unusual extensive comedo naevus without any systemic involvement, successfully managed with topical tretinoin and curettage.

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Area of Science:

  • Dermatology
  • Medical Genetics

Background:

  • Comedo naevi are benign hamartomas characterized by dilated follicular infundibula filled with keratinous material.
  • While extensive and systematized forms exist, individual lesions crossing the midline are uncommon.
  • Associated systemic abnormalities, including neurological, skeletal, and ophthalmological issues, are recognized in some cases.

Observation:

  • A patient presented with an extensive systematized comedo naevus.
  • The comedo naevi exhibited lesions that crossed the midline.
  • Notably, this patient lacked any reported neurological, skeletal, or ophthalmological abnormalities.

Findings:

  • The case represents an unusual presentation of comedo naevus due to its extensive nature, midline crossing, and absence of associated systemic conditions.
  • Topical tretinoin demonstrated efficacy in improving the texture and overall appearance of the comedonal lesions.
  • Surgical intervention, specifically curettage, was effective in managing larger individual comedo naevi.

Implications:

  • This case expands the clinical spectrum of comedo naevi, suggesting that extensive midline-crossing lesions can occur in the absence of systemic involvement.
  • It underscores the potential benefit of topical retinoids in managing the cosmetic aspects of comedo naevi.
  • The successful use of curettage indicates its utility for discrete, larger lesions within extensive presentations.

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