Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

T-cell clonality in immune responses.

M K Maini1, G Casorati, P Dellabona

  • 1Dept of Sexually Transmitted Diseases, Royal Free and University College Medical School, Mortimer Market off Capper St, London, UK WC1E 6AU. m.maini@ucl.ac.uk

Immunology Today
|June 4, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fasting mimicking diet in mice delays cancer growth and reduces immunotherapy-associated cardiovascular and systemic side effects.

Nature communications·2023
Same author

Group 1 CD1-restricted T cells and the pathophysiological implications of self-lipid antigen recognition.

Tissue antigens·2015
Same author

Defective natural killer cell anti-viral capacity in paediatric HBV infection.

Clinical and experimental immunology·2014
Same author

Immunological intervention with monoclonal antibodies.

Immunology today·2014
Same author

Interferon, β-2-microglobulin and immunoselection in the pathway to malignancy A blinkered view from Nag's Head Yard.

Immunology today·2014
Same author

Toll-like receptor 9-independent responsiveness of human monocytes to microbial DNA.

Scandinavian journal of immunology·2013

New methods analyze T-cell composition. This review explores T-cell clonality differences between CD4+ and CD8+ T-cell subsets during immune responses and steady states.

Area of Science:

  • Immunology
  • T-cell biology
  • Clonal analysis

Background:

  • Methodological advances enable detailed analysis of T-cell populations.
  • Understanding T-cell clonality is crucial for immune response studies.

Purpose of the Study:

  • To review current data on T-cell clonality in acute immune responses and steady-state conditions.
  • To investigate the reasons behind observed differences in clonality between CD4+ and CD8+ T-cell subsets.

Main Methods:

  • Review of existing literature and data on T-cell clonality.
  • Comparative analysis of clonal composition in CD4+ and CD8+ T-cell subsets.

Main Results:

  • Significant differences in clonality exist between CD4+ and CD8+ T-cell subsets.

Related Experiment Videos

  • Clonality patterns vary between acute immune responses and steady-state situations.

    • Conclusions:

    • T-cell subset-specific differences in clonality are a key feature of adaptive immunity.
    • Further research is needed to fully elucidate the functional implications of these clonal disparities.