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Bone mineral density in adults with Down's syndrome
N Angelopoulou1, V Souftas, A Sakadamis
1Department of Physical Education and Sports Science, Aristotle University of Thessaloniki, Greece.
European Radiology
|June 4, 1999
Summary
Individuals with Down's syndrome (DS) have significantly lower bone mineral density (BMD) in their lumbar spine compared to controls. This increased osteoporosis risk may stem from hypotonia and lifestyle factors.
Area of Science:
- Endocrinology
- Gerontology
- Genetics
Background:
- Down's syndrome (DS) is associated with premature aging and skeletal abnormalities.
- Osteoporosis risk in aging individuals with DS requires further investigation.
Purpose of the Study:
- To determine if adults with Down's syndrome exhibit an increased risk of osteoporosis.
- To compare bone mineral density (BMD) in DS individuals versus age-matched controls.
Main Methods:
- Dual-energy X-ray absorptiometry (DXA) was used to measure lumbar spine BMD.
- BMD measurements were taken in 22 adults with DS and compared to 27 healthy controls.
Main Results:
- Individuals with DS showed significantly lower lumbar spine BMD than controls (p < 0.001).
- DS males had 9% lower BMD than DS females.
- Lower BMD may be linked to muscular hypotonia, sedentary lifestyle, and comorbidities.
Conclusions:
- Adults with Down's syndrome have a higher risk of osteoporosis.
- Further research should explore bone metabolism, endocrine function, and genetic factors related to chromosome 21.