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Diffusion MRI in patients with transient ischemic attacks.

C S Kidwell1, J R Alger, F Di Salle

  • 1University of California at Los Angeles, CA, USA. ckidwell@ucla.edu

Stroke
|June 4, 1999
PubMed
Summary
This summary is machine-generated.

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Diffusion MRI detects ischemic abnormalities in nearly half of transient ischemic attack (TIA) patients. These findings can indicate a developing infarct or be reversible, impacting diagnosis and treatment.

Area of Science:

  • Neuroimaging
  • Neurology
  • Radiology

Background:

  • Diffusion MRI is valuable for ischemic stroke but understudied in transient ischemic attack (TIA).
  • Systematic investigation of diffusion MRI in TIA patients is needed.

Purpose of the Study:

  • To investigate the utility of diffusion MRI in patients with transient ischemic attack (TIA).
  • To compare diffusion MRI findings in TIA patients with those in completed stroke patients.

Main Methods:

  • Collected clinical, conventional MRI, and diffusion MRI data from 42 TIA patients.
  • Compared TIA imaging data with 23 completed stroke patients.

Main Results:

  • 48% of TIA patients showed focal abnormalities on diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC) imaging.

Related Experiment Videos

  • TIA lesions were less pronounced and smaller than in stroke patients.
  • Diffusion MRI findings altered suspected TIA localization and mechanism in over one-third of patients.

    • Conclusions:

    • Diffusion MRI identifies ischemic abnormalities in nearly half of TIA patients.
    • Findings suggest diffusion MRI changes in TIA may be reversible in some cases or indicate an impending infarct.
    • Diffusion MRI has significant clinical utility, frequently changing diagnostic and mechanistic assessments.