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Related Experiment Videos

Olfactory identification and psychosis.

K M Striebel1, B Beyerstein, R A Remick

  • 1Graduate Program in Neuropsychology, Simon Fraser University, Burnaby, B.C., Canada.

Biological Psychiatry
|June 5, 1999
PubMed
Summary

Treatment-refractory schizophrenia patients show impaired olfactory identification, similar to affective disorder groups. Antipsychotic medication further reduced smell identification in affective disorder patients.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Olfactory research

Background:

  • Olfactory identification deficits are common in schizophrenia.
  • This study examines treatment-refractory schizophrenia (T-RS) and affective disorder patients.

Purpose of the Study:

  • To investigate olfactory identification performance in T-RS patients.
  • To compare T-RS olfactory function with affective disorder patients on/off antipsychotics.

Main Methods:

  • 16 T-RS patients, 16 controls, 19 affective disorder patients on antipsychotics, and 20 affective disorder patients off antipsychotics were assessed.
  • The University of Pennsylvania Smell Identification Test (UPSIT) was used.

Main Results:

  • T-RS patients had significantly lower olfactory identification than controls.

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  • T-RS olfactory performance did not differ from either affective disorder group.
  • Affective disorder patients on antipsychotics performed worse than those not on antipsychotics.

    • Conclusions:

    • Olfactory deficits in T-RS may be linked to psychotic symptomotology.
    • Antipsychotic medication may negatively impact olfactory identification.