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Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
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Visual working memory deterioration preceding relapse in psychosis.

C L M Hui1, Y K Li1, A W Y Li1

  • 1Department of Psychiatry,University of Hong Kong,Hong Kong SAR,People's Republic of China.

Psychological Medicine
|June 17, 2016
PubMed
Summary
This summary is machine-generated.

Working memory decline predicts psychosis relapse. Visual working memory deterioration 2 months before relapse offers early warning signs in first-episode psychosis patients, independent of symptom worsening.

Keywords:
Early psychosispredictorsrelapseschizophreniaworking memory

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Cognitive Psychology

Background:

  • Relapse is common after first-episode psychosis but poorly understood.
  • Predicting relapse is crucial for effective patient management.
  • Cognitive function changes may offer insights into psychosis relapse mechanisms.

Purpose of the Study:

  • To investigate if working memory deterioration precedes relapse in remitted first-episode psychosis patients.
  • To identify potential early predictors of relapse in psychosis.

Main Methods:

  • Prospective monitoring of visual and verbal working memory in a 1-year randomized controlled trial.
  • Medication continuation (quetiapine) versus discontinuation (placebo) in remitted first-episode psychosis patients.
  • Monthly assessment of relapse, working memory, and stressful life events.

Main Results:

  • Visual working memory deterioration 2 months before relapse was significantly associated with increased relapse risk (OR 3.07).
  • Increased stressful life events 1 month before relapse also predicted recurrence (OR 2.11).
  • Medication discontinuation strongly predicted relapse (OR 5.52).

Conclusions:

  • Visual working memory deterioration may indicate early brain dysfunction preceding psychotic relapse.
  • This cognitive decline is a potential early warning sign, not a baseline predictor.
  • Identifying such predictors enhances understanding of brain processes underlying psychosis relapse.