Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[New data on acid-labile alpha-interferon].

O N Shcheglovitova

    Voprosy Virusologii
    |June 8, 1999
    PubMed
    Summary
    This summary is machine-generated.

    Abnormal alpha-interferon-alpha-acid-labile interferon (alpha-ALI) in blood indicates disease severity. Its composition and acid lability are key prognostic markers in AIDS and autoimmune diseases.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Lipophilic Prodrug of Methotrexate in the Membrane of Liposomes Promotes Their Uptake by Human Blood Phagocytes.

    Acta naturae·2020
    Same author

    IFN-α, IFN-β, and IFN-γ Have Different Effect on the Production of Proinflammatory Factors Deposited in Weibel-Palade Bodies of Endothelial Cells Infected with Herpes Simplex Virus Type 1.

    Bulletin of experimental biology and medicine·2016
    Same author

    [Human interferon modulates infected vascular endothelium function].

    Vestnik Rossiiskoi akademii meditsinskikh nauk·2014
    Same author

    Effects of gold nanoparticles on erythrocyte hemolysis.

    Bulletin of experimental biology and medicine·2014
    Same author

    [Adhesion molecules expressed in vascular endothelial cells in natural immunity against viral infections].

    Vestnik Rossiiskoi akademii meditsinskikh nauk·2011
    Same author

    [Changing the protective properties of the receptor domain of protective antigen anthrax exotoxin, depending on the orientation of the presentation on nanoparticles].

    Bioorganicheskaia khimiia·2011

    Area of Science:

    • Immunology
    • Virology

    Context:

    • Abnormal alpha-interferon-alpha-acid-labile interferon (alpha-ALI) is detected in patients with AIDS and autoimmune diseases.
    • alpha-ALI comprises alpha-interferon and gamma-interferon, contributing to its acid lability.

    Purpose:

    • To review new concepts regarding the composition and properties of alpha-ALI.
    • To explore the prognostic significance of alpha-ALI in various diseases.

    Summary:

    • Increased serum alpha-ALI and its acid lability are poor prognostic indicators in Acquired Immunodeficiency Syndrome (AIDS).
    • Decreased alpha-ALI levels correlate with clinical improvement in some autoimmune diseases, suggesting its pathogenic role.
    • In vitro studies demonstrate gamma-interferon's activating effect, including in models of HIV infection.

    Related Experiment Videos

    Impact:

    • Understanding alpha-ALI's role can improve disease prognostication and therapeutic strategies.
    • The ratio of alpha- and gamma-interferons within alpha-ALI appears crucial for its clinical effects.