Related Experiment Videos
Novel triazole 2'-deoxy-4'-thionucleosides: stereoselective synthesis and biological evaluation
G Inguaggiato1, M Jasamai, J E Smith
1Welsh School of Pharmacy, Cardiff University.
Nucleosides & Nucleotides
|June 8, 1999
Abstract:
A study on the use of protecting groups led to the employment of the para-methoxybenzoyl (pMB) group as a directing group in the synthesis of novel triazole 2'-deoxy-4'-thionucleosides. Use of the pMB group gave alpha:beta ratios of 1:6 in the glycosylation step with azidotrimethylsilane. A series of novel triazoles were generated for in vitro antiviral evaluation.