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Updated: Aug 16, 2026

Molecular Evolution of the Tre Recombinase
Published on: May 29, 2008
Protein evolution by molecular breeding
1Maxygen Incorporated, 515 Galveston Drive, Redwood City, CA 94063, USA. jeremy_minshull@maxygen.com
Abstract:
Natural evolution has guided the development of 'molecular breeding' processes used in the laboratory for the rapid modification of subgenomic sequences including single genes. The most significant recent development has been the in vitro permutation of natural diversity. Homologous recombination of multiple related sequences produced high-quality libraries of chimeric sequences encoding proteins with functions that differ dramatically from any of the parents. Increasingly powerful screening methods are also being developed, allowing these libraries to be screened for novel biocatalysts.
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