[Renin-angiotensin-aldosterone system in rats with neurogenic stress]

A moderate neurogenic stress was induced in adult male rats by crowding for a period of 1 and 7 days. The content of angiotensin I and the activity of renin in the blood plasm aldosterone concentration in the peripheral blood plasma considerably. Seven days after the beginning of the neurogenic stress the content of aldosterone in the blood plasma considerably. Seven days after the beginning of the neurogenic stress the content of aldosterone in the blood and the adrenal tissue was determined radioimmunologically. Crowding of rats for 24 hours led to a marked increase of aldosterone content in the adrenal glands, failed to alter the content of this hormone in the blood, decreased the activity of renin and angiotensin I content in the blood and the adrenal glands of rats proved to fall; as to the activity of renin and the amount of angiotensin I in the peripheral blood plasma - it rose. The problem on the causes of dissociation observed in the renin-angiotensin-aldosterone system in response to the neurogenic stress of various duration is discussed.