[Bilateral breast metastases from prostatic carcinoma: a case report]

Area of Science:

• Oncology
• Pathology

Background:

• Advanced prostate cancer (Stage D2) management often involves chemoendocrine therapy and radiotherapy.
• Estrogen therapy, such as diethylstilbestrol diphosphate, has been used in prostate cancer treatment.

Observation:

• A 49-year-old male patient developed bilateral breast enlargement.
• Palpable, non-tender masses were detected in both breasts.
• Needle biopsy revealed poorly differentiated adenocarcinoma with positive prostate-specific antigen staining.

Findings:

• The breast masses were diagnosed as metastatic adenocarcinoma originating from the prostate gland.
• The patient experienced rapid progression and died 3 months post-diagnosis of breast metastases.
• Autopsy confirmed diffuse lymphogenous metastatic disease.

Implications:

• Metastatic prostatic carcinoma to the breast is an uncommon presentation.
• Potential contributing factors include lymphogenous metastasis and increased local vascular/lymphatic supply due to exogenous estrogens.