Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Apoptosis and gastrointestinal tract.

R Ciccocioppo¹, A Di Sabatino, G Gasbarrini

¹Department of Medicine, University of L'Aquila, Italy.

Italian Journal of Gastroenterology and Hepatology

|June 11, 1999

Summary

Gastrointestinal stem cells regulate tissue size through programmed cell death (apoptosis). Dysregulation of apoptosis contributes to diseases like IBD and cancer, offering therapeutic targets.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Serological assessment of PRO-C16 (type XVI collagen formation) reflects intestinal fibrostenotic strictures in patients with crohn's disease.

BMC gastroenterology·2025

Same author

Clinical and atopic features of patients with wheat allergy dependent on augmentation factors (WALDA) presenting with urticaria: a monocentric study.

European annals of allergy and clinical immunology·2025

Same author

A 1-year follow-up study on checkpoint inhibitor-induced colitis: results from a European consortium.

ESMO open·2024

Same author

Omega 5-gliadin allergy in patients with recurrent acute urticaria.

European annals of allergy and clinical immunology·2024

Same author

Golimumab improves health-related quality of life of patients with moderate-to-severe ulcerative colitis: Results of the go-care study.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·2023

Same author

The role of heparin in reducing in-hospital complications and three-month mortality rates in hospitalized COVID-19 patients.

European journal of internal medicine·2022

Area of Science:

Gastroenterology and Molecular Biology
Cell Biology and Disease Mechanisms

Background:

The gastrointestinal tract relies on stem cell proliferation and programmed cell death (apoptosis) to maintain tissue homeostasis.
Apoptosis is crucial for regulating intestinal size and function, with its dysregulation implicated in various gastrointestinal pathologies.

Purpose of the Study:

To review the mechanisms of apoptosis in the gastrointestinal tract.
To explore the clinical relevance of apoptosis in gastrointestinal diseases and its potential as a therapeutic target.

Main Methods:

Literature review of biochemical pathways regulating apoptosis.
Analysis of the role of apoptosis in gastrointestinal disease pathogenesis.
Discussion of therapeutic strategies targeting apoptosis.

Main Results:

Apoptosis is essential for normal gastrointestinal tissue turnover.
Imbalances in apoptotic signaling contribute to diseases such as gastritis, celiac disease, and inflammatory bowel diseases.
Inhibition of apoptosis can lead to the development of neoplastic clones.

Conclusions:

Understanding apoptosis mechanisms in the gut is key to developing novel therapeutic strategies.
Targeting apoptotic pathways offers a promising avenue for treating gastrointestinal disorders.
Further research into apoptosis regulation can significantly impact gastrointestinal disease management.

Related Experiment Videos