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Experimental observations on the integration of bladder and urethral function.

E J McGuire

    Transactions of the American Association of Genito-Urinary Surgeons
    |January 1, 1976
    PubMed
    Summary

    Pelvic nerve stimulation relaxes both smooth and skeletal muscles in the urethra, indicating a dual component to urethral resistance. This response involves spinal reflexes and beta-receptors, crucial for understanding bladder and urethral function.

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    Area of Science:

    • Neuroscience
    • Urology
    • Physiology

    Background:

    • Understanding the neural control of the lower urinary tract is essential for diagnosing and treating bladder dysfunction.
    • The interplay between smooth and skeletal muscle components of the urethral sphincter is not fully elucidated.

    Purpose of the Study:

    • To investigate the effects of pelvic sympathetic and pudendal nerve stimulation on bladder and urethral pressure.
    • To determine the muscular components contributing to urethral resistance.
    • To explore the role of spinal reflexes and beta-receptors in these responses.

    Main Methods:

    • Stimulation of pelvic sympathetic and pudendal nerves in 60 anesthetized cats.
    • Measurement of bladder and urethral pressures.
    • Pharmacological blockade with propranolol to assess receptor involvement.

    Main Results:

    • Urethral resistance comprises both smooth and skeletal muscle elements, both of which relax upon pelvic nerve stimulation.
    • A spinal-mediated reflex, reciprocal inhibition of the detrusor-external sphincter, can be triggered by pelvic or pudendal nerve stimulation.
    • Pelvic nerve stimulation-induced urethral smooth muscle pressure loss was inhibited by propranolol, indicating beta-receptor involvement.

    Conclusions:

    • The urethra possesses both smooth and skeletal muscle components contributing to its resistance.
    • Reciprocal inhibition is a key spinal reflex governing detrusor-external sphincter coordination.
    • Beta-adrenergic receptors play a significant role in the smooth muscle relaxation of the urethra during pelvic nerve stimulation.

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