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Reappearance of founder virus sequence in human immunodeficiency virus type 1-infected patients
A C Karlsson1, H Gaines, M Sällberg
1Divisions of Clinical Virology, Department of Immunology, Microbiology, Pathology and Infectious Diseases, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden. Annika.Karlsson@impi.ki.se
Journal of Virology
|June 11, 1999
Abstract:
Different patterns of temporal evolution in human immunodeficiency virus type 1 V3 and p17 regions are described for eight patients studied during the first years following primary infection. In samples from three patients, a rapid replacement of the major sequence occurred but the original sequence reappeared later simultaneously with clinical deterioration and increased plasma viral load.