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Osteoarthritis-susceptibility locus on chromosome 11q, detected by linkage
K Chapman1, Z Mustafa, C Irven
1Wellcome Trust Centre for Human Genetics, Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom.
American Journal of Human Genetics
|June 12, 1999
Abstract:
We present a two-stage genomewide scan for osteoarthritis-susceptibility loci, using 481 families that each contain at least one affected sibling pair. The first stage, with 272 microsatellite markers and 297 families, involved a sparse map covering 23 chromosomes at intervals of approximately 15 cM. Sixteen markers that showed evidence of linkage at nominal P