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Serum and urine selenium concentrations in patients with cardiovascular diseases and relationship to other
M Navarro-Alarcón1, H López-Garcia de la Serrana, V Pérez-Valero
1Department of Nutrition and Bromatology, Faculty of Pharmacy, University of Granada, Granada, Spain.
Insights
Low selenium levels in serum and urine were observed in patients with acute myocardial infarction and ischemic cardiomyopathy, highlighting selenium's antioxidant role and the body's homeostasis regulation in cardiovascular disease.
Area of Science:
- Cardiology
- Nutritional Biochemistry
- Environmental Health
Background:
- Cardiovascular diseases (CVDs) pose a significant global health burden.
- Selenium (Se) is an essential trace element with known antioxidant properties.
- Dysregulation of essential nutrient levels can impact chronic disease development and progression.
Purpose of the Study:
- To investigate serum and urine selenium concentrations in patients diagnosed with cardiovascular diseases.
- To explore the relationship between selenium levels and specific cardiovascular conditions like acute myocardial infarction (AMI) and ischemic cardiomyopathy.
- To assess the potential role of selenium as an antioxidant in the context of AMI.
Main Methods:
- Hydride generation atomic absorption spectrometry was employed for precise selenium level determination.
- Serum and urine samples were collected from patients with diagnosed cardiovascular diseases and healthy control groups.
- Statistical analyses, including correlation tests, were performed to evaluate relationships between variables.
Main Results:
- Significantly lower mean serum selenium concentrations were found in patients with AMI and ischemic cardiomyopathy compared to controls.
- A significant positive correlation was observed between serum triglyceride levels and serum selenium concentration in AMI patients (r = 0.59, p < 0.05).
- Mean urine selenium concentrations were also significantly lower in AMI patients than in the control group (p < 0.05).
Conclusions:
- Reduced serum and urine selenium levels are associated with acute myocardial infarction and ischemic cardiomyopathy.
- Selenium's role as an antioxidant is reinforced in the context of acute myocardial infarction.
- The observed decrease in selenium levels suggests a physiological response to maintain selenium homeostasis during cardiovascular disease.
Abstract:
Serum and urine selenium levels were determined in patients with cardiovascular diseases by hydride generation atomic absorption spectrometry. Mean serum Se concentrations measured in patients with acute myocardial infarction (AMI; n = 32) or with ischemic cardiomyopathy (n = 50) were significantly lower than those determined in control groups. In AMI patients, serum triglyceride levels showed a positive significant correlation with the serum Se concentration (r = 0.59, p < 0.05). This result reinforces the important role of Se as an antioxidant agent in this disease. Mean urine Se concentrations of AMI patients (n = 33) were also significantly lower to those determined in the control group (p < 0. 05). This reaction of the organism contributes to regulate the Se homeostasis to keep the body Se status as high as possible.