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What are surrogate outcome measures and why do they fail in clinical research?
1Department of Neurology and Health Evaluation Sciences, University of Virginia, Charlottesville, VA 22908, USA. kj4v@virginia.edu
Neuroepidemiology
|June 12, 1999
Abstract:
Surrogate outcome measures have been of interest in clinical research for a long time because of their potential ability to save time and cost. The literature, however, has numerous examples of failed surrogate measures. The definition of a surrogate outcome measure, its consideration in clinical stroke research and some of the potential mechanisms for failure of surrogate measures will be discussed.