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Antineutrophil cytoplasmic antibodies in diffuse panbronchiolitis
1Department of Pulmonary Medicine, Jichi Medical School, Tochigi, Japan.sugiyuki@jichi.ac.jp
Background:
There are some reports of the coexistence of chronic suppurative lung diseases such as cystic fibrosis and systemic vasculitis. Diffuse panbronchiolitis has the same characteristics as chronic recurrent sinopulmonary infection and respiratory bronchiolitis.
Methods:
Serum samples from 30 patients with diffuse panbronchiolitis and 57 patients with other pulmonary diseases were tested to find the titer of myeloperoxidase antineutrophil cytoplasmic antibodies (MPO-ANCA).
Results:
We found MPO-ANCA positivity in 4 patients with diffuse panbronchiolitis but not in those with other pulmonary diseases.
Conclusions:
Our findings show that MPO-ANCA is positive in some patients with diffuse panbronchiolitis. Careful attention should be paid to the combination of chronic pulmonary infection and various vasculitis.