Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drugs Used in Lower Respiratory Disorders: Overview01:17

Drugs Used in Lower Respiratory Disorders: Overview

Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
Antiasthma Drugs: β2-Adrenoceptor Agonists01:25

Antiasthma Drugs: β2-Adrenoceptor Agonists

Bronchodilators are critical in managing asthma, a chronic respiratory condition characterized by airway constriction due to inflammation and hyper-reactivity. Specifically, bronchodilators ease this constriction by relaxing the bronchial muscles, facilitating easier breathing.
One class of bronchodilators includes β2-adrenoceptor agonists. These agents target the β2-adrenoceptors located on bronchial smooth muscle cells. By stimulating these receptors, β2-agonists induce relaxation in these...
Antiasthma Drugs: Methylxanthines01:24

Antiasthma Drugs: Methylxanthines

Theophylline, a member of the methylxanthine class of bronchodilators, has long been used in asthma management. While its exact mechanism of action is not fully understood, it is believed to have multiple effects on various cellular processes.
Theophylline is thought to inhibit phosphodiesterase enzymes, increasing intracellular levels of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). This rise in cAMP and cGMP concentrations stimulates cardiac function,...
Antiasthma Drugs: Muscarinic Receptor Antagonists01:20

Antiasthma Drugs: Muscarinic Receptor Antagonists

Muscarinic receptor antagonists, also known as antimuscarinic agents, are a class of bronchodilators used to treat asthma, although they are more commonly used to treat COPD. They work by inhibiting the action of acetylcholine (ACh), a neurotransmitter, on muscarinic receptors found in the airways.
Antimuscarinic agents compete with ACh for the same binding site on the muscarinic receptors. By binding to these receptors, they inhibit the downstream effects of ACh and block the parasympathetic...
Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Inhaled Medications01:23

Inhaled Medications

Inhaled medications are crucial for managing chronic obstructive pulmonary disease (COPD) and asthma. They are essential for effective treatment and control, ensuring optimal respiratory health and well-being. Inhaled medication delivers drugs directly to the lungs, providing a rapid onset of action and reducing systemic side effects compared to oral or injectable medications. Three primary types of inhalation devices are used to administer these medications: nebulizers, metered-dose inhalers...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Selective A1 adenosine receptor antagonism augments beta-adrenergic-induced renin release in vivo.

The American journal of physiology·1995
Same author

Synthesis and preliminary evaluation of [11C]KF15372, a selective adenosine A1 antagonist.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine·1995
Same author

[Clinical assessment for prognostic factors related to recurrence and progression in superficial bladder cancer].

Nihon Hinyokika Gakkai zasshi. The japanese journal of urology·1995
Same author

Purification of an angiogenesis inhibitor from culture medium conditioned by a human chondrosarcoma-derived chondrocytic cell line, HCS-2/8.

Biochimica et biophysica acta·1995
Same author

Demonstration of endothelin (ET) receptors on cultured rabbit chondrocytes and stimulation of DNA synthesis and calcium influx by ET-1 via its receptors.

Cell biology international·1995
Same author

Small amounts of exogenous IL-4 increase the severity of encephalitis induced in mice by the intranasal infection of herpes simplex virus type 1.

Journal of immunology (Baltimore, Md. : 1950)·1995
Same journal

Design, Synthesis, and Biological Evaluation of Potent Cognition-Improved Compounds Targeting AMPA Receptor Based on CX717.

Chemical & pharmaceutical bulletin·2026
Same journal

Associations of Bioactive Constituents of Aster yomena with Environmental Variables.

Chemical & pharmaceutical bulletin·2026
Same journal

Focused Beam Reflectance Measurement as a Complementary Tool for Monitoring Disintegration and Drug Release Processes of Sustained-Release Formulations: A Preliminary Investigation.

Chemical & pharmaceutical bulletin·2026
Same journal

A Nonclassical N-Methyl Amidation Using N,N-Disubstituted Aminophosphonium Salts.

Chemical & pharmaceutical bulletin·2026
Same journal

Synthesis of 2,3,4,5-Tetrahydro-1,5-benzoxazepine Derivatives via Alkoxy Migration Induced by N-O Bond Cleavage of N-Aryl Isoxazolidines.

Chemical & pharmaceutical bulletin·2026
Same journal

Evaluation of the Effect of the Introduction of Disubstituted Amino Acids Aib on the Lipid Membrane into Amphipathic Helical Peptides K9L9.

Chemical & pharmaceutical bulletin·2026
See all related articles

Related Experiment Video

Updated: Jun 30, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
11:51

Facile Preparation of 4-Substituted Quinazoline Derivatives

Published on: February 15, 2016

New bronchodilators. II. 3H-imidazo[4,5-c]quinolin-4(5H)-ones.

F Suzuki1, T Kuroda, H Hayashi

  • 1Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., Shizuoka, Japan.

Chemical & Pharmaceutical Bulletin
|December 1, 1992
PubMed
Summary
This summary is machine-generated.

Novel imidazoquinolinone derivatives were synthesized and tested for bronchodilatory effects. The compound 5-ethyl-3-methyl-3H-imidazo[4,5-c]quinolin-4(5H)-one demonstrated significant in vivo activity, outperforming theophylline.

More Related Videos

Disposable Dosators for Pulmonary Insufflation of Therapeutic Agents to Small Animals
04:22

Disposable Dosators for Pulmonary Insufflation of Therapeutic Agents to Small Animals

Published on: March 30, 2017

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System
07:28

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

Published on: April 6, 2017

Related Experiment Videos

Last Updated: Jun 30, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
11:51

Facile Preparation of 4-Substituted Quinazoline Derivatives

Published on: February 15, 2016

Disposable Dosators for Pulmonary Insufflation of Therapeutic Agents to Small Animals
04:22

Disposable Dosators for Pulmonary Insufflation of Therapeutic Agents to Small Animals

Published on: March 30, 2017

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System
07:28

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

Published on: April 6, 2017

Area of Science:

  • Medicinal Chemistry
  • Pharmacology
  • Organic Synthesis

Background:

  • Asthma and bronchospasm are significant respiratory conditions requiring effective bronchodilatory treatments.
  • Imidazo[4,5-c]quinolin-4(5H)-one scaffold represents a potential pharmacophore for developing novel therapeutic agents.

Purpose of the Study:

  • To synthesize and characterize a series of novel 3-substituted imidazo[4,5-c]quinolin-4(5H)-one derivatives.
  • To evaluate the bronchodilatory activity of these novel compounds in vitro and in vivo.
  • To identify structure-activity relationships guiding the development of potent bronchodilators.

Main Methods:

  • Synthesis of imidazo[4,5-c]quinolin-4(5H)-ones via reaction with electrophiles under basic conditions.
  • In vitro evaluation using the Schultz-Dale reaction on guinea-pig trachea.
  • In vivo assessment of protective effects against antigen inhalation-induced bronchospasm in guinea-pigs.

Main Results:

  • A series of 3-substituted imidazo[4,5-c]quinolin-4(5H)-ones (2a-w) were successfully synthesized.
  • Short alkyl chains (methyl, ethyl) at the 3-position were crucial for potent bronchodilatory activity, particularly in vivo.
  • 5-Ethyl-3-methyl-3H-imidazo[4,5-c]quinolin-4(5H)-one (21) showed the highest in vivo potency, exceeding theophylline by at least fivefold.

Conclusions:

  • The synthesized imidazoquinolinone derivatives hold promise as novel bronchodilatory agents.
  • Structural modifications, specifically short alkyl chains at the 3-position, significantly enhance in vivo bronchodilatory efficacy.
  • Compound 21 represents a lead candidate for further development in the treatment of bronchospastic disorders.