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Updated: Aug 7, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Structural Characterization of New 8,17-Epoxybriarane Diterpenoids from the Octocoral Briareum stechei
Yuan-Hao Liu1,2, Chih-Kai Hsu3,4, Liu-Guo Zheng4
1Department of Surgery, Division of Cardiovascular Surgery, Kaohsiung Armed Forces General Hospital, Kaohsiung 802301, Taiwan.
Abstract:
An encrusting, algae-associated octocoral, Briareum stechei, afforded three 8,17-epoxybriarane diterpenoids, including the known compound briaexcavatolide B (1) and two previously undescribed analogues, briastecholides Q (2) and R (3). The absolute configuration of 1 was established for the first time by single-crystal X-ray diffraction analysis. The planar structures and relative configurations of 2 and 3 were determined through extensive spectroscopic analyses. In bioactivity evaluation, compound 2 exhibited cytotoxic effects toward the human acute lymphoblastic leukemia cell lines Molt-4 and CCRF-CEM.
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