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[Lymphocytic meningitis by mumps virus: epidemiologic, clinical, serologic and evolutive analysis of 28 cases]
F Rodríguez-Vidigal1, L Redondo, F J Aguilar
1Hospital Comarcal de Llerena, Badajoz.
Background:
Mumps is a viral infection which is particularly found in children and adolescents and one of its manifestations is as lymphocytary meningitis. The aim of this study was to analyze the clinical, epidemiologic and serologic characteristics of the cases of meningitis by the mumps virus (MMV) observed during an epidemic of mumps.
Subjects And Methods:
Twenty-eight cases of MMV diagnosed from December 1, 1994 to August 31, 1995 during an epidemic of mumps in the south of the province of Badajoz (Spain) were analyzed. Demographic, clinical, analytical and evolutive data were obtained.
Results:
Cases predominated in the winter and summer in adolescents and youths (mean age 16.9 years) with a male:female relationship of 3:1. On admission most patients presented fever, headache, and parotid hypertrophy. Orchitis was observed in half of the males. No case of encephalitis was seen. Hyperproteinorrhachia was observed in the cephalorrhachidian fluid of 79% of the cases and hypoglucorrhachia was found in only two patients (7%). The course was benign, except in four patients (14%) who had sequelae (headache, unilateral hyperacusia and testicular discomfort).
Conclusions:
The epidemiologic and liquoral data of MMV in adolescents agree with those described in series of children. Nonetheless, the absence of encephalic involvement and the high proportion of orchitis is of note.
Insights
Mumps virus meningitis (MMV) in adolescents during an epidemic presented with fever, headache, and parotid swelling. Most cases recovered fully, but a notable proportion of males developed orchitis.
Area of Science:
- Virology
- Epidemiology
- Neurology
Context:
- Mumps virus (MMV) is a common childhood infection.
- Meningitis is a known complication of mumps.
- An epidemic provided an opportunity to study MMV in adolescents.
Purpose:
- To analyze clinical, epidemiologic, and serologic features of mumps virus meningitis (MMV).
- To understand MMV characteristics during a mumps epidemic.
Summary:
- Analyzed 28 MMV cases during a 1994-1995 mumps epidemic in Badajoz, Spain.
- Cases were predominantly in adolescents (mean age 16.9 years), with a 3:1 male predominance.
- Common symptoms included fever, headache, and parotid hypertrophy; 50% of males experienced orchitis. No encephalitis cases were observed.
- Cerebrospinal fluid showed hyperproteinorrhachia in 79% and hypoglucorrhachia in 7%.
- The course was generally benign, with 14% experiencing sequelae like headache, hyperacusis, or testicular discomfort.
Impact:
- Findings on MMV in adolescents align with data from pediatric populations.
- The high incidence of orchitis and lack of encephalitis in this adolescent cohort are significant observations.
- Provides valuable insights into the clinical spectrum of mumps virus meningitis in an adolescent population during an epidemic.