Related Experiment Videos
[Acute self-induced poisoning with carbamazepine]
H Thabet1, N Brahmi, I Zagdoudi
1Centre d'assistance médicale urgente, Montfleury Tunis, Tunisie. nadhaf@gnet.tn
Presse Medicale (Paris, France : 1983)
|June 15, 1999
Summary
Acute carbamazepine intoxication is increasingly common, presenting with neurological, cardiovascular, and metabolic symptoms. Prompt symptomatic treatment and activated carbon are crucial for favorable outcomes in these poisoning cases.
Area of Science:
- Clinical Toxicology
- Pharmacology
- Epidemiology
Context:
- Acute voluntary carbamazepine intoxication is a growing concern.
- Understanding its epidemiological, clinical, and toxicological profiles is essential.
Purpose:
- To detail the epidemiological, clinical, toxicological, and therapeutic aspects of acute carbamazepine intoxication.
- To analyze 17 hospitalized cases.
Summary:
- Predominant symptoms include neurological disturbances (agitation, coma, seizures), mydriasis, and cardiovascular signs.
- Hyponatremia was a frequent finding, with a mean serum carbamazepine level of 24 mg/l.
- Ten patients required respiratory support; symptomatic treatment and activated carbon led to favorable outcomes.
Impact:
- Highlights the increasing incidence and severity factors of carbamazepine poisoning.
- Emphasizes the need for symptomatic management and specific treatments like activated carbon.
- Informs clinical practice for managing carbamazepine overdose.