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Serum amyloid A (SAA): a concise review of biology, assay methods and clinical usefulness
1Department of Clinical Pathology, Jichi Medical School, Minamikawachi, Tochigi, Japan. toshiyam@jichi.ac.jp
Clinical Chemistry and Laboratory Medicine
|June 16, 1999
Abstract:
Serum amyloid A (SAA) is a family of proteins encoded in a multigene complex. Acute phase isotypes SAA1 and SAA2 are synthesized in response to inflammatory cytokines. SAA and C-reactive protein (CRP) are now the most sensitive indicators for assessing inflammatory activity. In viral infection and kidney allograft rejection, SAA proved more useful than CRP. Development of convenient assay methods for SAA will facilitate its use in clinical laboratories.