Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Proton magnetic resonance spectroscopy.

Zimmerman1, Wang

  • 1Department of Radiology, Children's Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA

Critical Reviews in Neurosurgery : CR
|November 30, 1999
PubMed
Summary

Proton magnetic resonance spectroscopy (MRS) allows in vivo measurement of brain biochemistry. Future advancements aim to enhance understanding of brain metabolite composition using advanced multi-voxel techniques.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Computer Simulation Modeling for Recreation Management: A Study on Carriage Road Use in Acadia National Park, Maine, USA.

Environmental management·1999
Same author

An Analysis of Higher Order Vibration-Torsion-Rotation Interactions and Spectra for a Molecule with an Internal Rotor.

Journal of molecular spectroscopy·1999
Same author

Preparation of Palladium Ultrafine Particles in Reverse Micelles.

Journal of colloid and interface science·1999
Same author

Prediction of photosynthetic production rate of ethylene using a recombinant cyanobacterium

Journal of theoretical biology·1999
Same author

Conformational Structure of Triblock Copolymers by FT-Raman and FTIR Spectroscopy.

Journal of colloid and interface science·1999
Same author

Surface Characters and Adsorption Behavior of Pb(II) onto a Mesoporous Titanosilicate Molecular Sieve.

Journal of colloid and interface science·1999

Area of Science:

  • Neuroimaging
  • Biochemistry
  • Medical Physics

Background:

  • Proton magnetic resonance spectroscopy (MRS) is a non-invasive technique for in vivo biochemical analysis of brain tissue.
  • It uses standard magnetic resonance (MR) scanners and head coils, integrating with conventional MR imaging.
  • Current MRS applications primarily focus on large single voxels to study conditions like brain tumors and metabolic diseases.

Purpose of the Study:

  • To review the current state and future directions of proton magnetic resonance spectroscopy (MRS) in neurobiology.
  • To highlight the evolution of MRS technology and its potential for broader applications.
  • To emphasize the shift towards multi-voxel techniques for more comprehensive brain analysis.

Main Methods:

  • Utilizing magnetic resonance (MR) scanners and head coils for both imaging and spectroscopy.
  • Employing variable echo times for data acquisition in single-voxel measurements.
  • Developing and implementing multi-voxel techniques for examining smaller tissue volumes.

Main Results:

  • Established MRS as a tool for characterizing biochemical changes in various neurological conditions.
  • Demonstrated the feasibility of using single-voxel MRS for diagnosing brain tumors, demyelinating diseases, abscesses, and metabolic disorders.
  • Identified the need for advanced techniques to improve spatial resolution and metabolite detection.

Conclusions:

  • Proton MRS is a valuable tool for in vivo brain biochemistry assessment.
  • Technological advancements, particularly multi-voxel techniques, promise to expand the understanding of brain metabolite composition.
  • Future research will focus on smaller voxels and increased metabolite identification for deeper insights into brain function and disease.

Related Experiment Videos