Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Reaction-diffusion microtubule concentration patterns occur during biological morphogenesis.

C Papaseit1, L Vuillard, J Tabony

  • 1Département de Biologie Moléculaire et Structurale, CEA Grenoble, France.

Biophysical Chemistry
|June 17, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

1H, 13C and 15N assignment of the GNA1946 outer membrane lipoprotein from Neisseria meningitidis.

Biomolecular NMR assignments·2010
Same author

Microtubule self-organisation depends upon gravity.

Advances in space research : the official journal of the Committee on Space Research (COSPAR)·2002
Same author

Membrane interaction of Escherichia coli hemolysin: flotation and insertion-dependent labeling by phospholipid vesicles.

Journal of bacteriology·2001
Same author

Microtubule self-organization is gravity-dependent.

Proceedings of the National Academy of Sciences of the United States of America·2000
Same author

Control of NF-kappa B transcriptional activation by signal induced proteolysis of I kappa B alpha.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·1999
Same author

A complex containing betaTrCP recruits Cdc34 to catalyse ubiquitination of IkappaBalpha.

FEBS letters·1999

Reaction-diffusion processes create biological patterns. Microtubule concentration variations, observed in vitro and in Drosophila, support this theory, linking chemical reactions to morphogenesis.

Area of Science:

  • Biophysics
  • Developmental Biology
  • Chemical Kinetics

Background:

  • Reaction-diffusion systems explain biological pattern formation and morphogenesis.
  • Microtubules are key components in cellular structure and dynamics.
  • Spontaneous self-organization of microtubules in vitro suggests underlying physical-chemical principles.

Purpose of the Study:

  • To investigate if reaction-diffusion principles explain observed microtubule self-organization.
  • To determine if microtubule concentration variations are present in these patterns.
  • To explore the role of reaction-diffusion in Drosophila embryogenesis.

Main Methods:

  • In vitro assembly of microtubules and observation of self-organization.
  • Analysis of microtubule concentration variations in self-organized structures.

Related Experiment Videos

  • Comparative study of microtubule patterns in vitro and during Drosophila embryogenesis, including experiments with ligated eggs.

    • Main Results:

    • In vitro assembled microtubules spontaneously form stationary, striped macroscopic structures.
    • These structures exhibit substantial microtubule concentration variations, consistent with reaction-diffusion theory.
    • Microtubule patterns in Drosophila embryogenesis show similar dimension-dependent variations as in vitro systems.

    Conclusions:

    • The study provides evidence for reaction-diffusion mechanisms driving microtubule self-organization.
    • Observed microtubule patterns in vitro and in Drosophila morphogenesis are consistent with reaction-diffusion theory.
    • Reaction-diffusion structures are implicated in the fundamental processes of biological morphogenesis.