Related Experiment Video
Updated: Aug 19, 2026

Heterokaryon Technique for Analysis of Cell Type-specific Localization
Published on: March 11, 2011
[Early nuclear modifications related to cellular activation: from histology to molecular cytopathology (1967-1997)]
1Faculté de Médecine Cochin-Port-Royal, Laboratoire d'Histologie Embryologie Cytogénétique, Paris.
Abstract:
The nuclear chromatin structure and function are altered as soon as the first steps of cellular activation induced by membrane stimulation. Different studies carried on lymphatic tissues as well as isolated cell suspensions (lympho-monocytes) demonstrate that an early and transitory chromatin dispersion, visualised by nuclear refringency (1967), is related to the genome derepression allowing DNA transcription mechanism. This is linked to the expression of c-fos proto-oncogene and that of specific proteins synthesis. This occurs before c myc expression and could play a role in the regulation of surface antigens expression. Independent from the induction of cell proliferation, but related to cell differentiation, the early and transitory chromatin dispersion as well as the influence of c-fos related to proteic system activator (AP1) is discussed in referring to recent studies (1997), as well as the regulation factors of the chromatin filament structure.
Related Concept Videos
Covalently Linked Protein Regulators
These groups modify specific amino acids in a protein.
Spreading of Chromatin Modifications
Writers
The writer is an enzyme that can...
Nuclear Protein Sorting
Proteins targeted to the nucleus carry nuclear localization signals or NLS recognized by import receptors in the cytosol. Similarly, proteins with nuclear export signals are recognized by export receptors. Import and export receptors are...
Nuclear Localization Signals and Import
Tumor Progression
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Introduction to Nuclear Reprogramming

