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Hematopoietic stem/progenitor cell mobilization. A continuing quest for etiologic mechanisms
1Department of Medicine, University of Washington, Seattle 98195-7710, USA. thalp@u.washington.edu
Annals of the New York Academy of Sciences
|June 18, 1999
Summary
Understanding how blood stem cells and mature blood cells leave the bone marrow (hematopoiesis) and how drugs mobilize them is crucial. Research is uncovering the complex molecular signals involved in this process.
Area of Science:
- Hematology
- Cell Biology
- Molecular Biology
Background:
- Physiologic egress of hemopoietic stem/progenitor cells (HSPCs) and mature hemopoietic cells from bone marrow to circulation is not well understood.
- Mechanisms of drug-induced mobilization of HSPCs are largely unraveled.
- A molecular hierarchy model for hemopoietic cell mobilization, similar to leukocyte extravasation, is lacking.
Purpose of the Study:
- To elucidate the in vivo mechanisms governing the egress and mobilization of hemopoietic cells.
- To identify the roles, specificities, and interactions of signaling molecules involved in mobilization.
Main Methods:
- Utilizing mouse models with targeted disruptions of cytoadhesion or signaling molecules.
- Investigating signals from stromal and hemopoietic cells.
Main Results:
- Emerging insights into the complex, multi-step process of mobilization.
- Identification of key molecular players and their interactions.
Conclusions:
- Mobilization is a complex process involving sequential changes in adhesion and migration.
- Further research using advanced models is critical for a comprehensive understanding.