Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neurotoxicity of dextrorphan.

G G Ortiz1, J M Guerrero, R J Reiter

  • 1Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, USA. orve@foreigner.class.udg.mx

Archives of Medical Research
|June 18, 1999
PubMed
Summary

Dextrorphan, a low-affinity NMDA antagonist, causes neurotoxicity in rats, similar to high-affinity antagonists. This study evaluated dextrorphan

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Relationship between inflammation and oxidative stress and its effect on multiple sclerosis.

Neurologia·2024
Same author

Trophic factors intervention regenerates the nestin-expressing cell population in a model of perinatal excitotoxicity: Implications for perinatal brain injury and prematurity.

Integrative molecular medicine·2022
Same author

A synchrotron computed tomography dataset for validation of longitudinal tensile failure models based on fibre break and cluster development.

Data in brief·2021
Same author

Effect of melatonin administration on the PER1 and BMAL1 clock genes in patients with Parkinson's disease.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2020
Same author

Large-scale cultivation ofSolanum chrysotrichum cells: Production of the antifungal saponin SC-1 in 10-I airlift bioreactors.

Plant cell reports·2019
Same author

A comparative study of melatonin and immunomodulatory therapy with interferon beta and glatiramer acetate in a mouse model of multiple sclerosis.

Neurologia·2018

Area of Science:

  • Neuroscience
  • Pharmacology

Background:

  • Noncompetitive NMDA antagonists like phencyclidine (PCP) and dizocilpine (MK-801) show neuroprotective potential but cause neuronal injury.
  • Dextrorphan, a low-affinity NMDA antagonist, is also considered for neuroprotection.

Purpose of the Study:

  • To evaluate the neurotoxic effects of dextrorphan.

Main Methods:

  • Male Sprague-Dawley rats received intraperitoneal injections of saline or dextrorphan (30 mg/kg).
  • Brains were examined for histopathological changes 30 minutes post-injection.

Main Results:

  • Dextrorphan administration resulted in hyperchromatic, shrunken nuclei with chromatin condensation and disruption.
  • Pyramidal neurons in the retrosplenial cortex exhibited granular and vacuolated cytoplasm.

Related Experiment Videos

  • Status spongiosus (spongy degeneration) of the neuropil was observed.

    • Conclusions:

    • The observed morphological changes in neurons are consistent with those induced by high-affinity NMDA antagonists.
    • Dextrorphan exhibits neurotoxic properties, similar to other noncompetitive NMDA antagonists.