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Acanthamoeba keratitis with live isolates treated with cryosurgery and fluconazole
1Department of Ophthalmology, Morningside Clinic, Johannesburg, South Africa. percy@icon.co.za
American Journal of Ophthalmology
|June 18, 1999
Abstract
Purpose:
To report live, active trophozoites in an eye with Acanthamoeba keratitis that resembled Acanthamoeba polyphagia in the anterior chamber fluid obtained by transcorneal tap.
Method:
After prediagnostic therapy had failed, we performed cryosurgery to break the corneal cell walls and treated the patient with oral fluconazole.
Results:
The condition resolved after 8 weeks of oral fluconazole therapy. Residual leukoma was treated by corneal graft.
Conclusion:
Live, motile Acanthamoeba can be isolated from an anterior chamber tap; combination therapy with oral fluconazole after corneal cryosurgery may be effective.